There has been a serious crash on the A27 Pevensey Bypass.
Three vehicles are believed to have collided at 3.24pm, leaving two people trapped.
East Sussex Fire and Rescue Service say they have three appliances from Eastbourne and Pevensey on the scene. Police are also in attendance.
Highways England say the road is closed in both directions from the A22 Golden Jubilee Way and the A259 Pevensey Roundabout.
SECAmb have also confirmed the air ambulance is on the scene, with paramedics dealing with injuries.
Long delays are being reported along Golden Jubilee Way and through Westham as traffic is diverted away from the area.
Eastbourne Police say the road is likely to remain closed for a few hours.
Image Credit: Dan Jessup