Two people have been flown to hospital after a head-on collision on the A27 Pevensey bypass this afternoon (27 March).
Two vehicles were involved in the crash at 3.20pm.
Fire crews were called to the scene to reports of two people being trapped.
Sussex Police say the road has re-opened in both directions.
Meanwhile, a biker is also in a serious condition after a separate crash on the A27 between Polegate and the Drusillas roundabout.
The motorbike was in a collision with a lorry at Folkington Road at 5.10pm.
Sussex Police tell Eastbourne Buzz the road is expected to remain closed in both directions for several hours.
Photo Credit: Dan Jessup